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Homologous recombination (HR) facilitates genome duplication beneath replication stress by repairing DNA strand breaks or singlestrand DNA (ssDNA) gaps and restarting stalled replication forks (Aguilera and G ezGonz ez, 2008; Li and Heyer, 2008; Branzei and Foiani, 2010).178432-48-9 structure Through these processes, the strand exchange protein Rad51 coats ssDNA and enables ssDNA pairing using a homologous sequence to template new DNA synthesis.PMID:23715856 This leads to the formation of HR intermediates, like Dloop and HollidayThis report was published on-line ahead of print in MBoC in Press (http://www .molbiolcell.org/cgi/doi/10.1091/mbc.E12110836) on June 19, 2013. Present address: Department of Biochemistry and Molecular Pharmacology, New York University College of Medicine, New York, NY 10016. Address correspondence to: Xiaolan Zhao ([email protected]). Abbreviations made use of: FACS, fluorescenceactivated cell sorting; HR, homologous recombination; MMS, methyl methanesulfonate; Xmol, Xshaped structure. 2013 Chen et al. This article is distributed by The American Society for Cell Biology below license from the author(s). Two months just after publication it is readily available for the public under an Attribution oncommercial hare Alike 3.0 Unported Inventive Commons License (http://creativecommons.org/licenses/byncsa/3.0). “ASCB” “The American Society for Cell Biology” and “Molecular Biology of the Cell are registered trademarks on the American Society of Cell Biology.junction structures. Numerous other proteins also play important roles in HR intermediate metabolism under these situations. In Saccharomyces cerevisiae, these include things like variables that market HR intermediate formation or maintenance, for example the DNA helicase Mph1 as well as the Rad51 paralogue Shu complicated (Mankouri et al., 2007, 2009; Chen et al., 2009; Choi et al., 2010), and those that market.
